Non sedating antihistamines urticaria treatment
Wheal numbers were reduced after treatment with 20 mg, but not 5 mg, desloratadine.
In conclusion, the beneficial effects of non-sedating H (Accepted May 16, 2012.) Acta Derm Venereol 2012; 92: XX–XX.
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METHODS Ethics This study (identifier NCT00598611, Eudra CT-No: 2006-001431-22) was approved by the Independent Ethics Committee of Berlin (Ethikkommission des Landes Berlin) and the Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, Bf Ar M).
CSU often lasts for years, sometimes even decades, and has a substantial impact on patients’ quality of life (3–5).Marcus Maurer, Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité – Universitätsmedizin Berlin, Charitéplatz 1, DE-10117 Berlin, Germany.E-mail: [email protected] spontaneous urticaria (CSU) is one of the most frequent skin disorders.In allergic rhinitis, several studies point towards a better efficacy of modern non-sedating antihistamines if given continuously (8–10).
The only study in CSU examining both treatment approaches was published by Grob and colleagues (11), who showed that daily treatment with desloratadine resulted in significantly better quality of life compared with on-demand therapy.Study design This was a randomized, double-blind, parallel group, single-dose study. Rescue medication (cetirizine 10 mg, and additional clemastine 1 mg if required) was allowed for severe symptoms, but its use had to be documented by the patients and was reviewed.